Ruotolo, Fred

Blaine joined Jones Day in March 2007. He drafts and prosecutes patents and assists in patent due diligence and freedom-to-operate investigations.

Blaine attended Columbia University, where his studies (in the group of Professor James L. Leighton) focused on new synthetic methods for the syntheses of biologically active chiral molecules. During these studies, Blaine was involved in the development of new, highly selective silicon-based reagents for the asymmetric syntheses of homoallylic alcohols. These reagents have the convenient property of being storable for extended periods of time and offer unprecedented access to highly congested chiral tertiary alcohols and their derivatives, a group to which the selective serotonin reuptake inhibitor, escitalopram, belongs.

Blaine's articles include "Highly Diastereo- and Enantioselective Reagents for Aldehyde Crotylation," Organic Letters, 2004, 6, 4375-4377 (coauthored with P.J. Lombardi and J.L. Leighton) and "Enantioselective Allylation of 2-Hydroxyphenyl Ketones," Angew. Chem. Int. Ed., 2006, 45(23), 3811-3813 (coauthored with N.Z. Burns, I.A. Powelson, and P.Y. Ng). Blaine is also a recipient of the Dow Chemical Foundation Scholarship.